Description
High amount of tartrate-resistant acid phosphatase (TRACP) is expressed by boneresorbing osteoclasts and activated macrophages1. Two forms of TRACP circulate in human blood, known as TRACP 5a and TRACP 5b2. TRACP 5b is derived from osteoclasts and TRACP 5a from macrophages3.
· Measures TRACP 5b activity that is released specifi cally from osteoclasts.
· No interference with TRACP 5a or other phosphatases.
· Hemolysis has no effect on results.
· No diurnal variation.
· Not affected by functional disorders of kidney and liver.
· No dietary influences.
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Code |
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Format |
96 Wells |
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Intended Use |
For IVD Use* |
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Calibrators |
2 x 6 vials with 0.5 ml each |
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Controls |
2 x 2 vials with 0.5 ml each |
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Sample Type** |
Serum and EDTA-plasma |
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Sample Volume |
100 µL |
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Assay Range |
0.5-10 U/L |
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Sample Pretreatment |
No |
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Limit of Quantitation |
< 0.5 U/L |
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*USA: For Research Use Only. Not for use in diagnostic procedures. **The same specimen type must be used throughout a follow-up study. |
1. Yaziji H, Janckila AJ, Lear SC, Martin AW, Yam LT 1995 Immunohistochemical detection of tartrate-resistant acid phosphatase in non-hematopoietic human tissues. Am J Clin Pathol 104:397-402.
2. Lam KW, Li CY, Yam LT, Desnick RJ 1981 Comparison of the tartrate-resistant acid phosphatase in Gaucher ¢â‚¬™s disease and leukemic reticuloendotheliosis. Clin Biochem 14:177-181.
3. Janckila AJ, Neustadt DH, Nakasato YR, Halleen JM, Hentunen T, Yam LT 2002 Serum tartrate-resistant acid phosphatase isoforms in rheumatoid arthritis. Clin Chim Acta. 320:49-58.
